In this course, we read papers about emerging biomedical technologies and talk to the people behind them.

Throughout the semester, we covered over 50 different papers. Check out our blog posts, presentations, and videos.

 

  • Use of Red Blood Cell Membranes to Camouflage from The Immune System
    The use of photothermal therapy (PTT) has been a preferred technique for tumour ablation, due to its non-invasive nature. It utilizes injection of nanoparticles to convert near infrared (NIR) light into heat in situ, hence reducing tumours. These nanomediators’ performance can be enhanced when exposed to a magnetic field. However, a major hurdle in its…
  • Learning by imitation with the STIFF-FLOP surgical robot: a biomimetic approach inspired by octopus movements
    Transcript: What does an octopus and surgery have in common? The STIFF-FLOP. Minimally invasive surgery, or MIS, is a surgery in which tools enter the body through narrow openings (usually 2mm-5mm) to perform surgical tasks. This method, while being less invasive, and therefore safer than open surgery, is limited by flexibility…
  • Preventing implant infections using Cicadas and Catkins.
    Infection from implant surgery is a common issue. Improving the implant’s surface antibacterial properties offers promising perspective in preventing these infections, seemingly a good alternative to antibiotics. Cicada’s wings nanopillar structures have been shown to kill bacteria with the simple physical action that its structure exerts on them. This gives it long-term antibacterial properties. However,…
  • Bioinspired micro/nano fabrication on dental implant–bone interface
    It is not uncommon today to use a dental implant to replace a missing tooth. Several phenomena can be responsible, but in general the success or not of the implant is at the interface between the bone and the implant. This study therefore focuses on the manufacture of a dental bone-implant interface based on the…
  • Multipôles et microfluidique ouverte : à l'aube d’une révolution en sciences de la vie ?
    J’entre dans le bureau de Pr. Gervais. Des feuilles gribouillées d’équations traînent sur son bureau, aux côtés d’un coffret contenant plusieurs technologies microfluidiques issues de ses recherches, prêt à les présenter à tout moment. Café à la main, il m’invite à m’assoir. Je viens discuter avec lui de son article « Microfluidic multipoles: theory and…
  • Cartographie de la moelle épinière : un entretien avec le Dr Julien Cohen-Adad
    J’ai eu le plaisir d’avoir une entrevue avec le Dr. Julien Cohen-Adad, afin de discuter de son travail, et plus particulièrement de son article « White matter atlas of the human spinal cord with estimation of partial volume effect »1, publié en 2015 dans NeuroImage. Le professeur Julien Cohen-Adad fait partie du laboratoire NeuroPoly à Polytechnique Montréal,…
  • Une vision moléculaire, pour permettre aux chirurgiens de voir le cancer.
    “Souvent, il est impossible de distinguer visuellement les cellules cancéreuses des cellules saines. Il subsiste donc fréquemment des cellules cancéreuses après la chirurgie, ce qui entraîne une récidive du cancer et un mauvais pronostic. Plus le chirurgien enlève de cellules cancéreuses, plus le pronostic du patient est positif.”   Le Professeur Frédéric Leblond, directeur du…
  • Artificial cornea for patients at high risk for rejection of donor tissue
    Vision is the most important sense for the perception of our environment. We perceive up to 80% of our impressions from our surrounding through our eyes and loss of this sense adversely affects a person’s quality of life. The human eye that is protected by eyelids has a complex structure and anatomy and damage to…
  • Technologies émergentes en biomécanique
    Le professor Delphine Perié-Curnier, de l'école Polytechnique de Montréal, travaille actuellement sur plusieurs projets autour de la biomécanique. Elle travaille, entre autres, sur la modélisation de la colonne vertébrale pour traiter la scoliose chez les enfants, ainsi qu'à des applications de l'IRM pour l'élastographie de la colonne et du coeur. C'est sur ces sujet de…
  • Descendre à l’échelle nanoscopique pour comprendre notre mémoire
    D’où nous viens la mémoire, cette faculté du cerveau à retenir des informations et à s’en servir pour apprendre ? On sait aujourd’hui qu’elle trouve son origine dans les échanges d’informations entre les neurones. Mais comment ce mécanisme, encore méconnu, façonne-t-il notre capacité d’apprentissage ?  C’est dans l’optique de répondre à ces questions que Paul…
  • Nouvelles méthodes de normalisation d'images biomédicales pour le deep learning : interview du Dr Kadoury.
    Le Dr Kadoury est  professeur adjoint à l’école Polytechnique Montréal en génie biomédical à polytechnique Montréal ainsi qu’un chercheur au CRCHUM. Il compte à son actif plus de 50 publications. Il est également titulaire de la chair…
  • Boosting the potential of stem cells in cardialogy: an interview with Dr. Nicolas Noiseux
    In early March, I had the pleasure to discuss with Dr. Nicolas Noiseux about his work on stem cells at the CR-CHUM and his contribution to “The IMPACT-CABG trial: A multicenter, randomized clinical trial of CD133+ stem cell therapy during coronary artery bypass grafting for ischemic…
  • D'une curiosité de laboratoire jusqu'à une thérapie in vivo, une entrevue avec le Professeur Michel Meunier
      Références : [1]. Wilson, A.M. et al. (2018). In Vivo Laser-Mediated Retinal Ganglion Cell Optoporation Using KV1.1 Conjugated Gold Nanoparticles. Nano Letters, 18(11), 6981- 6988. Tiré de https://doi.org/10.1021/acs.nanolett.8b0 2896 [2].https://www.polymtl.ca/expertises/meunier-michel [3].https://educationnewscanada.com/article/education/level/university/1/733350/a-major-step-toward-non-viral-ocular-gene-therapy-using-laser-and-nanotechnology.html
  • NeuroTracker : Une méthode innovatrice pour suivre la progression des commotions cérébrales dans le sport
    Je pose la scène suivante. Un joueur de football américain tente d’intercepter une passe. Celui-ci est en mouvement. Il doit à la fois être conscient de son environnement ainsi que de la trajectoire et de la vitesse du ballon. Plusieurs paramètres sont en jeu dans cette situation. Comment fait le cerveau pour interpréter cette scène…
  • A new lab-on-chip to trap molecules with dielectrophoresis
    An interview with Dr. Sara Mahshid By determining the order of the nucleotides in several DNA strands, DNA sequencing helps understanding genetic mechanisms. The ability to see where a specific gene is offers a new way for the treatment of genetic diseases: regulatory instructions in the DNA can be altered by adding genes or by…
  • Au cœur (en 3D) de la recherche en ultrasons !
    Comme vous le savez certainement, la chauve-souris utilise les ultrasons afin de se localiser dans l’espace, mais également de repérer sa proie et déterminer sa vitesse par effet Doppler pour l’attraper en plein vol. L’imagerie ultrasonore, à l’instar de la chauve-souris,…
  • Before it goes to trial, the battle against reproducible polyplexes
    Lack of larger-scale production and reproducible production for the generation of chitosan based polyplexe. By Laurence Bérubé, April 10th 2019 ____________________________________________________________________________________________________   Even though science has improved greatly over the last decades, there is still unresolved problems. Among them, genetic disorders. Currently the treatments consist of minimizing the symptoms rather than treating the underlying cause,…
  • Standardizing gene editing with microfluidics
      Gene editing is a very common process in biology. Cancer research, T-cell treatment preparations or gene therapy are some examples of application. However, the editing remains time-consuming (typically, it takes several months to engineer T-cells for a cancer treatment) and, moreover, results tend to…
  • Q&A with Dr. Atefeh Abdolmanafi: Characterization of coronary artery pathological formations from OCT imaging using deep learning
    Coronary artery disease is the most common heart disease in the US, killing over 370 000 people annually. [1] Many factors contribute to the development of coronary artery disease and early detection of symptoms can greatly reduce the risk of heart infarcts and death. In recent years, optical coherence tomography (OCT) has become increasingly useful…
  • Delineation of Cortical Pathology in Multiple Sclerosis using Multi-Surface Magnetization Transfer Ratio Imaging
    The Montreal Neurological Institute (MNI) is a research and medical center located in Downtown Montreal, where great physicians, researchers and Engineers from Montreal like Dr. David Rudko, get together for analyzing, training and developing new procedures for treating neurological diseases. The MNI is part of McGill University Health Center, which it is dedicated for neuroscience.…
  • L’imagerie de tissus osseux, un pas de géant pour l’ultrason!
    J’ai récemment eu le plaisir de discuter avec Dr. Pierre Bélanger, professeur au département de génie mécanique de l’École de Technologie Supérieure (ETS), sur ses récentes recherches portant sur la tomographie ultrasonore à des fins de diagnostic de l’ostéoporose. Dr. Pierre Bélanger Diplômé en génie mécanique de l’université Laval puis d’une maîtrise en acoustique à…
  • Delivering the goods: an interview with Dr. Xavier Banquy on the production of drug-delivery vectors
    Effective delivery of drugs to their targets has long plagued researchers and clinicians. There are also concerns related to the large-scale production of drug-delivery tools required for commercialization, especially in light of our aging population who present an increasing strain on our healthcare system. Therapy for chronic diseases like hypertension, cancer, and diabetes require the…
  • How a biochemist copied nature to engineer DNA towards heart failure detection
    Problematic Some diseases require treatments that can have adverse effects on other organs. This is particularly the case of heart failure, which can be treated with a class of drugs, angiotensin-converting enzymes (ACE) inhibitors, such as Ramipril or Quinapril. Unfortunately, these drugs can potentially be toxic to the kidneys. In treating patients with heart failure,…
  • Tracking Down Epilepsy: Investigating Brain Networks Across Scales
    By Émile Lemoine   “Epilepsy and autism are incredible models to study brain networks.”. Professor Boris Bernhardt, founder and Principal Investigator of the MICA (Montreal Imaging and Connectome Analysis) Lab, at the McConnell Brain Imaging Center of the Montreal Neurological Institute, dedicates his research to these diseases that offer a window into brain development, functional…
  • Engineering Nanoparticles for Nitrous Oxide Release during Surgery with Dr Yahia
    Nanomaterials have a great potential for biomedical applications. When considering their use in drug delivery, they must be engineered and tailored for targeted delivery and to avoid toxicity. Dr Yahia and his colleagues investigate the use of Superparamagnetic Iron Oxide Nanoparticles (SPIONs) for the delivery of Nitrous Oxide (NO) during surgeries that require general anesthesia.…
  • Preparing for an influenza pandemic: A discussion with Professor Amine Kamen from the Viral Vectors and Vaccines Bioprocessing Group
    Our capacity to respond to an influenza pandemic threat is presently limited by the methods used to manufacture vaccines, as…
  • Autisme, le raisonnement moral lié à l'attention visuelle ?
    Le domaine de la psychologie utilise de plus en plus les nouvelles technologies à des fins de diagnostic ou d’analyse comportementale notamment. C’est dans cette optique que j’ai eu la chance de m’entretenir avec Dre Miriam Beauchamp qui est neuropsychologue de formation. Son domaine de recherche se divise en deux champs d’expertise : premièrement la neuropsychologie…
  • How Dr. Farivar and his colleagues came to build an accurate and economic research-grade gaze tracking system
    Eye trackers have a variety of applications, ranging from psychology research to marketing, product design, and software usability evaluation. I recently had the opportunity to meet Dr. Reza Farivar, professor and research director of the McGill Vision Research unit (MVR) to talk about a novel eye-tracking system called MVR Tracker, recently developed at Dr. Farivar’s Laboratory…
  • Le futur de la chirurgie cardio-vasculaire : des prothèses personnalisées?
    Nous avons eu la chance d’avoir une entrevue avec le professeur Gregory De Crescenzo, ancien titulaire d’une Chaire de recherche du Canada sur les biomatériaux protéinés, à propos de son article « A highly versatile adaptor protein for the tethering of growth factors to gelatin-based biomaterials »(2017)1 . Le travail de Dr De Crescenzo et…
  • A New Carbon Nanotube-Based Breast Cancer Drug Delivery System: Preparation and In Vitro Analysis Using Paclitaxel
    Prof. Satya Prakash, Department of Biomedical Engineering, McGill University Everyone is inquisitive. Some people are more than others. They are not pleased until a cogent answer is given. They must know exactly how and why. Curiosity is one of the greatest strengths of scientists. All the best scientists in the world possess this curiosity for the…
  • Une nouvelle génération de prothèse pour la réadaptation des enfants
    Il y a actuellement 1.6 million d’amputés aux États-Unis et ce nombre devrait atteindre 3.6 million d’ici 2050. On compte deux catégories d’amputés. Les amputés « traumatiques » suite à un accident, et les amputés « congénitaux » nés avec une malformation. Dans la population globale, les amputés traumatiques représentent la majorité des cas, notamment à cause des mutilés…
  • Étude d’implants dynamiques pour soigner la scoliose chez l’enfant
    Récemment j’ai eu le plaisir de rencontrer Isabelle Villemure et Anne-Laure Ménard pour discuter de leur article « Static and Dynamic Compression Application and Removal on the Intervertebral Discs of Growing Rats» (2016)1, rédigé dans le cadre du doctorat d’Anne-Laure. Isabelle Villemure (à gauche) et Anne-Laure Ménard (à droite) Anne-Laure Ménard est issue d’une école…
  • Augmented Realities: The Future of Image-Guided Neurosurgery?
    Augmented Realities: The Future of Image-Guided Neurosurgery?   IBIS: an OR ready open-source platform for image-guided Neurosurgery[2]   When it comes to neuroscience research, the Montreal Neurological Institute (Neuro) is a world-leading destination that has been contributing to the understanding and treatment of nervous system disorders since 1934. The NeuroImaging and Surgical Technologies (NIST) laboratory at…
  • Virtual Reality and Behavioural Sciences: a discussion with Prof. Patrice Renaud
    I had the pleasure to discuss with Prof. Patrice Renaud about his work inside the ARVIPL laboratory at the Philippe-Pinel Institute, and his contribution to "A pilot development of virtual stimuli depicting affective dispositions for penile plethysmography assessment of sex offenders". This study, published in 2014, laid the basis for an assessment protocol taking into…
  • Predicting seizures with wearable electrodes? An interview with Mohamad Sawan
    The city of Montreal has a strong history in epilepsy research. In the middle of the 20th century, a notable surgical procedure, the "Montreal Procedure", was developped by Dr. Penfield at McGill university. This procedure allowed to cure nearly 50% of the patients that received it. Since…
  • Interview with the Probabilistic Vision Group
    Interview with the Probabilistic Vision Group (PVG). Student: Christian S. Perone Click on the images below to zoom, or download the PDF version of the interview.
  • Data Science meets Neuroscience
    Interview with Drs. Karim Jerbi & Étienne Combrisson   On April 9, 2018, Dr. Karim Jerbi, PhD, and Étienne Combrisson, PhD, met with Dr. Nikola Stikov and I at the University of Montreal for a short interview to discuss their work, and their co-authored research article entitled “From intentions to actions: Neural oscillations encode motor…
  • Cerveau en santé, vieillissement en santé
    Une discussion avec le Pr Simon Duchesne, professeur agrégé au Département de Radiologie de l’Université Laval et chercheur au centre de recherche CERVO, sur la détection précoce de maladies neurodégénératives, sur la création d’un modèle de prédiction du vieillissement ainsi que sur les enjeux liés au traitement de données big data. Spécialisé en physique médicale,…
  • Comment Dr Nielsen Connaît vos Pires Cauchemars ?
    Le Dr Tore Nielsen est un chercheur qui s’intéresse au sommeil et plus particulièrement aux rêves et aux cauchemars. Son dernier article porte principalement sur le lien entre les cauchemars et les maladies mentales. J’ai choisi ce sujet car j’ai toujours moi-même été très intéressée par les rêves et le sommeil. Je fais moi-même beaucoup…
  • Tomographie optique diffuse, une méthode prometteuse?
    Tomographie optique diffuse, une méthode prometteuse? Par Simon Blais   Présentation du LIOM et du projet de recherche de Samuel Bélanger par Frédéric Lesage, directeur du laboratoire Le LIOM (Laboratoire d’Imagerie Optique et Moléculaire), situé à l’école Polytechnique de Montréal, dont les travaux portent sur les…
  • Le sommeil et l'éveil de la conscience
    Le sommeil est encore rempli de mystères et intéresse autant les chercheurs que le public. Ainsi, je me suis intéressée aux recherches effectuées au Centre d’études avancées en médecine du sommeil (CÉAMS) situé à l’Hôpital du Sacré-Coeur de Montréal. Je suis alors tombée sur un article très intéressant qui illustre les résultats d’une étude de…
  • To question or not to question? Dr. Jean Gotman sheds light on how he and his team are changing the way scientists think about EEG
    von Ellenrieder, N.,Dan, J., Frauscher, B., Gotman, J. “Sparse Asynchronous Cortical Generators Can Produce Measurable Scalp EEG Signals.” NeuroImage, vol. 138, Elsevier Inc., 2016, pp. 123–33, doi:10.1016/j.neuroimage.2016.05.067. Dr. Jean Gotman, engineer, professor, and neuroscientist at the Montreal Neurological Institute, is the director of his laboratory and namesake, The Gotman Laboratory. I recently had the pleasure…
  • Grasping the Future: Automating the Assistive Robot for Wheelchair Enabled Patients
    You’re thirsty. You see a water bottle in front you and you reach out to grab it. You bring it to your mouth to take a sip, and now you are refreshed! Yes, I have just described to you a task as banal as drinking from a bottle, but this might be a process that…
  • Capillaric circuits: the answer to rapid bacteria detection in urine
    Miniaturization is a trend in our society. Just like it was important to reduce the size of computers, miniaturization of chemical and biological laboratory processes to a sub-millimeter scale is crucial. This is a challenge microfluidics is trying to overcome. Microfluidics systems,…
  • Bile acids, a vehicle for anti-tumour drugs
    Breast cancer is the second common cancer in Canada. Chemotherapy is one of the main treatments for breast cancer which involves severe side effects. Doxorubicin is the current chemotherapy medication used for breast cancer. Professor Zhu and Alexander are developing a drug delivery system to encapsulate chemotherapeutic agents to increase their safety and transport efficacy.…
  • Reading the signs: Determining Alzheimer’s 10 years before onset
    A recent study has been published stating that it is possible to determine the signs of Alzheimer’s disease (AD) 10 years before normal clinical diagnosis.  The study, titled “Regionally specific changes in the hippocampal circuitry accompany progression of cerebrospinal fluid biomarkers in preclinical Alzheimer’s disease” [1], was published in late 2017 in the journal of…
  • Intravital assessment of myelin molecular order with polarimetric multiphoton microscopy
    Intravital assessment of myelin molecular order with polarimetric multiphoton microscopy By: Raphaël Turcotte, Danette J. Rutledge, Erik Bélanger, Dorothy Dill, Wendy B. Macklin & Daniel C. Côté Published the 19 August 2016 in Science Reports   Interview with Raphaël Turcotte                  Postdoctoral Researcher at the University of Oxford…